天麻研究報告

1: Manavalan A, Feng L, Sze SK, Hu JM, Heese K. New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics. J Proteomics. 2012 Apr 18;75(8):2468-79.

2: Wang J, Xiong X. Control strategy on hypertension in chinese medicine. Evid Based Complement Alternat Med. 2012;2012:284847.

3: Lee OH, Kim KI, Han CK, Kim YC, Hong HD. Effects of acidic polysaccharides from gastrodia rhizome on systolic blood pressure and serum lipid concentrations in spontaneously hypertensive rats fed a high-fat diet. Int J Mol Sci. 2012;13(1):698-709.

4: Shu C, Chen C, Zhang DP, Guo H, Zhou H, Zong J, Bian Z, Dong X, Dai J, Zhang Y, Tang Q. Gastrodin protects against cardiac hypertrophy and fibrosis. Mol Cell Biochem. 2012 Jan;359(1-2):9-16.

5: Tsai CF, Huang CL, Lin YL, Lee YC, Yang YC, Huang NK. The neuroprotective effects of an extract of Gastrodia elata. J Ethnopharmacol. 2011 Oct 31;138(1):119-25.

6: Huang CL, Yang JM, Wang KC, Lee YC, Lin YL, Yang YC, Huang NK. Gastrodia elata prevents huntingtin aggregations through activation of the adenosine A₂A receptor and ubiquitin proteasome system. J Ethnopharmacol. 2011 Oct 31;138(1):162-8.

7: Kim IS, Choi DK, Jung HJ. Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells. Molecules. 2011 Jun 24;16(7):5349-61.

8: Chen PJ, Liang KC, Lin HC, Hsieh CL, Su KP, Hung MC, Sheen LY. Gastrodia elata Bl. Attenuated learning deficits induced by forced-swimming stress in the inhibitory avoidance task and Morris water maze. J Med Food. 2011 Jun;14(6):610-7.

9: Shin EJ, Kim JM, Nguyen XK, Nguyen TT, Lee SY, Jung JH, Kim MJ, Whang WK, Yamada K, Nabeshima T, Kim HC. Effects of gastrodia elata bl on phencyclidine-induced schizophrenia-like psychosis in mice. Curr Neuropharmacol. 2011 Mar;9(1):247-50.

10: Shin EJ, Bach JH, Nguyen TT, Nguyen XK, Jung BD, Oh KW, Kim MJ, Ko SK, Jang CG, Ali SF, Kim HC. Gastrodia elata bl attenuates methamphetamine-induced dopaminergic toxicity via inhibiting oxidative burdens. Curr Neuropharmacol. 2011 Mar;9(1):118-21.

11: Shin EJ, Bach JH, Nguyen TT, Jung BD, Oh KW, Kim MJ, Jang CG, Ali SF, Ko SK, Yang CH, Kim HC. Gastrodia Elata Bl Attenuates Cocaine-Induced Conditioned Place Preference and Convulsion, but not Behavioral Sensitization in Mice: Importance of GABA(A) Receptors. Curr Neuropharmacol. 2011 Mar;9(1):26-9.

12: Park S, Kim da S, Kang S. Gastrodia elata Blume water extracts improve insulin resistance by decreasing body fat in diet-induced obese rats: vanillin and 4-hydroxybenzaldehyde are the bioactive candidates. Eur J Nutr. 2011 Mar;50(2):107-18.

13: Mishra M, Huang J, Lee YY, Chua DS, Lin X, Hu JM, Heese K. Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice. Biosci Trends. 2011;5(3):129-38.

14: Teong IW, Ko AA, Li M, Heese K, Liang W. Gastrodia elata decreases isoprenaline potency and enhances spontaneous phasic activity in the rat detrusor. Int J Physiol Pathophysiol Pharmacol. 2011;3(1):29-37..

15: An H, Kim IS, Koppula S, Kim BW, Park PJ, Lim BO, Choi WS, Lee KH, Choi DK. Protective effects of Gastrodia elata Blume on MPP+-induced cytotoxicity in human dopaminergic SH-SY5Y cells. J Ethnopharmacol. 2010 Jul 20;130(2):290-8.

16: Tong XK, Qiu H, Zhang X, Shi LP, Wang GF, Ji FH, Ding HY, Tang W, Ding K, Zuo JP. WSS45, a sulfated alpha-D-glucan, strongly interferes with Dengue 2 virus infection in vitro. Acta Pharmacol Sin. 2010 May;31(5):585-92.

17: Jang YW, Lee JY, Kim CJ. Anti-asthmatic activity of phenolic compounds from the roots of Gastrodia elata Bl. Int Immunopharmacol. 2010 Feb;10(2):147-54. Epub 2009 Oct 26.

18: Yu SS, Zhao J, Zheng WP, Zhao Y. Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in rats. Brain Res. 2010 Jan 13;1308:167-75.

19: Lee YJ, Hwang SM, Kang DG, Kim JS, Lee HS. Effect of Gastrodia elata on tumor necrosis factor-alpha-induced matrix metalloproteinase activity in endothelial cells. J Nat Med. 2009 Oct;63(4):463-7.

20: Yong W, Xing TR, Wang S, Chen L, Hu P, Li CC, Wang HL, Wang M, Chen JT, Ruan DY. Protective effects of gastrodin on lead-induced synaptic plasticity deficits in rat hippocampus. Planta Med. 2009 Aug;75(10):1112-7.

21: Descamps E, Petrault-Laprais M, Maurois P, Pages N, Bac P, Bordet R, Vamecq J. Experimental stroke protection induced by 4-hydroxybenzyl alcohol is cancelled by bacitracin. Neurosci Res. 2009 Jun;64(2):137-42.

22: Chen PJ, Hsieh CL, Su KP, Hou YC, Chiang HM, Sheen LY. Rhizomes of Gastrodia elata B(L) possess antidepressant-like effect via monoamine modulation in subchronic animal model. Am J Chin Med. 2009;37(6):1113-24.

23: Hwang SM, Lee YJ, Kang DG, Lee HS. Anti-inflammatory effect of Gastrodia elata rhizome in human umbilical vein endothelial cells. Am J Chin Med. 2009;37(2):395-406.

24: Teo CC, Tan SN, Yong JW, Hew CS, Ong ES. Evaluation of the extraction efficiency of thermally labile bioactive compounds in Gastrodia elata Blume by pressurized hot water extraction and microwave-assisted extraction. J Chromatogr A. 2008 Feb 22;1182(1):34-40.

25: Chen PJ, Hsieh CL, Su KP, Hou YC, Chiang HM, Lin IH, Sheen LY. The antidepressant effect of Gastrodia elata Bl. on the forced-swimming test in rats. Am J Chin Med. 2008;36(1):95-106.

26: Shuchang H, Qiao N, Piye N, Mingwei H, Xiaoshu S, Feng S, Sheng W, Opler M. Protective effects of gastrodia elata on aluminium-chloride-induced learning impairments and alterations of amino acid neurotransmitter release in adult rats. Restor Neurol Neurosci. 2008;26(6):467-73.

27: Wang S, Chen Y, He D, He L, Yang Y, Chen J, Wang X. Inhibition of vascular smooth muscle cell proliferation by serum from rats treated orally with Gastrodia and Uncaria decoction, a traditional Chinese formulation. J Ethnopharmacol. 2007 Dec 3;114(3):458-62.

28: Kim HJ, Hwang IK, Won MH. Vanillin, 4-hydroxybenzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia. Brain Res. 2007 Nov 21;1181:130-41.

29: Qiu H, Tang W, Tong X, Ding K, Zuo J. Structure elucidation and sulfated derivatives preparation of two alpha-D-glucans from Gastrodia elata Bl. and their anti-dengue virus bioactivities. Carbohydr Res. 2007 Nov 5;342(15):2230-6.

30: Heo JC, Woo SU, Son M, Park JY, Choi WS, Chang KT, Kim SU, Yoon EK, Kim YH, Shin HM, Lee SH. Anti-tumor activity of Gastrodia elata Blume is closely associated with a GTP-Ras-dependent pathway. Oncol Rep. 2007 Oct;18(4):849-53.

31: Jung TY, Suh SI, Lee H, Kim IS, Kim HJ, Yoo HS, Lee SR. Protective effects of several components of Gastrodia elata on lipid peroxidation in gerbil brain homogenates. Phytother Res. 2007 Oct;21(10):960-4.

32: Xu X, Lu Y, Bie X. Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons. Planta Med. 2007 Jun;73(7):650-4.

33: Lin LC, Chen YF, Tsai TR, Tsai TH. Analysis of brain distribution and biliary excretion of a nutrient supplement, gastrodin, in rat. Anal Chim Acta. 2007 May 8;590(2):173-9.

34: Ahn EK, Jeon HJ, Lim EJ, Jung HJ, Park EH. Anti-inflammatory and anti-angiogenic activities of Gastrodia elata Blume. J Ethnopharmacol. 2007 Apr 4;110(3):476-82.

35: Zeng X, Zhang Y, Zhang S, Zheng X. A microdialysis study of effects of gastrodin on neurochemical changes in the ischemic/reperfused rat cerebral hippocampus. Biol Pharm Bull. 2007 Apr;30(4):801-4.

36: Kim DS, Kim JY, Han YS. Alzheimer’s disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult. J Altern Complement Med. 2007 Apr;13(3):333-40.

37: Huang NK, Chern Y, Fang JM, Lin CI, Chen WP, Lin YL. Neuroprotective principles from Gastrodia elata. J Nat Prod. 2007 Apr;70(4):571-4.

38: Yang XD, Zhu J, Yang R, Liu JP, Li L, Zhang HB. Phenolic constituents from the rhizomes of Gastrodia elata. Nat Prod Res. 2007 Feb;21(2):180-6.

39: Hsieh CL, Lin JJ, Chiang SY, Su SY, Tang NY, Lin GG, Lin IH, Liu CH, Hsiang CY, Chen JC, Ho TY. Gastrodia elata modulated activator protein 1 via c-Jun N-terminal kinase signaling pathway in kainic acid-induced epilepsy in rats. J Ethnopharmacol. 2007 Jan 19;109(2):241-7.

40: Choi JH, Lee DU. A new citryl glycoside from Gastrodia elata and its inhibitory activity on GABA transaminase. Chem Pharm Bull (Tokyo). 2006 Dec;54(12):1720-1.

41: Zhou BH, Li XJ, Liu M, Wu Z, Ming Hu X. Antidepressant-like activity of the Gastrodia elata ethanol extract in mice. Fitoterapia. 2006 Dec;77(7-8):592-4.

42: Zeng X, Zhang S, Zhang L, Zhang K, Zheng X. A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro. Planta Med. 2006 Dec;72(15):1359-65.

43: Huang ZB, Wu Z, Chen FK, Zou LB. The protective effects of phenolic constituents from Gastrodia elata on the cytotoxicity induced by KCl and glutamate. Arch Pharm Res. 2006 Nov;29(11):963-8.

44: Liu Y, Tang X, Pei J, Zhang L, Liu F, Li K. Gastrodin interaction with human fibrinogen: anticoagulant effects and binding studies. Chemistry. 2006 Oct 16;12(30):7807-15.

45: Lee JY, Jang YW, Kang HS, Moon H, Sim SS, Kim CJ. Anti-inflammatory action of phenolic compounds from Gastrodia elata root. Arch Pharm Res. 2006 Oct;29(10):849-58.

46: Jung JW, Yoon BH, Oh HR, Ahn JH, Kim SY, Park SY, Ryu JH. Anxiolytic-like effects of Gastrodia elata and its phenolic constituents in mice. Biol Pharm Bull. 2006 Feb;29(2):261-5.

47: Yu SJ, Kim JR, Lee CK, Han JE, Lee JH, Kim HS, Hong JH, Kang SG. Gastrodia elata blume and an active component, p-hydroxybenzyl alcohol reduce focal ischemic brain injury through antioxidant related gene expressions. Biol Pharm Bull. 2005 Jun;28(6):1016-20.

48: Hsieh CL, Chen CL, Tang NY, Chuang CM, Hsieh CT, Chiang SY, Lin JG, Hsu SF. Gastrodia elata BL mediates the suppression of nNOS and microglia activation to protect against neuronal damage in kainic acid-treated rats. Am J Chin Med. 2005;33(4):599-611.

49: Huang NK, Lin YL, Cheng JJ, Lai WL. Gastrodia elata prevents rat pheochromocytoma cells from serum-deprived apoptosis: the role of the MAPK family. Life Sci. 2004 Aug 13;75(13):1649-57.

50: Mori A, Yokoi I, Noda Y, Willmore LJ. Natural antioxidants may prevent posttraumatic epilepsy: a proposal based on experimental animal studies. Acta Med Okayama. 2004 Jun;58(3):111-8.

51: Pyo MK, Jin JL, Koo YK, Yun-Choi HS. Phenolic and furan type compounds isolated from Gastrodia elata and their anti-platelet effects. Arch Pharm Res. 2004 Apr;27(4):381-5.

52: Lee KT, Kim BJ, Kim JH, Heo MY, Kim HP. Biological screening of 100 plant extracts for cosmetic use (I): inhibitory activities of tyrosinase and DOPA auto-oxidation. Int J Cosmet Sci. 1997 Dec;19(6):291-8.